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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6941 | PI-1840 | PI 1840 | PARP , Proteasome |
PI-1840(IC50 = 27 nM)is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L). | |||
T79742 | CARM1 degrader-2 | Histone Methyltransferase | |
PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated argininemethyltransferase (CARM1). It not only promotes the degradation of CARM1 ... | |||
T79741 | CARM1 degrader-1 | Histone Methyltransferase | |
PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1). This compound facilitates the degradation of CARM1 via the VHL-pro... |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPJ-01386 | STUB1 Protein, Human, Recombinant | Human | E. coli |
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ... | |||
TMPH-02300 | RAD23A Protein, Human, Recombinant (His) | Human | E. coli |
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chain... | |||
TMPH-01269 | SMURF2 Protein, Human, Recombinant (His) | Human | E. coli |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA... | |||
TMPH-02282 | Ubiquilin-1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa... | |||
TMPH-01531 | IKBKB Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A... | |||
TMPH-01532 | IKBKB Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A... |